| 2021-10-26 19:15:0026/10/2021 | Spartan Nomads vs Exeter University I | 19:15:007:15 pm | Division I | |
| 2021-10-28 19:45:0028/10/2021 | QE Crediton Chargers vs Torbay Tigers | 19:45:007:45 pm | Division I | |
| 2021-10-30 18:15:0030/10/2021 | Exeter University II vs K&S Autos | 18:15:006:15 pm | Division I | |
| 2021-11-01 20:15:0001/11/2021 | Exeter University I vs K&S Autos | 20:15:008:15 pm | Division I | |
| 2021-11-02 19:15:0002/11/2021 | Spartan Nomads II vs North Devon | 19:15:007:15 pm | Inter Division | |
| 2021-11-06 18:15:0006/11/2021 | Exeter University II vs QE Crediton Chargers | 18:15:006:15 pm | Division I | |
| 2021-11-08 20:15:0008/11/2021 | Exeter University I vs Newton Abbot Pacers | 20:15:008:15 pm | Inter Division | |
| 2021-11-11 19:45:0011/11/2021 | QE Crediton Chargers vs Taunton Tornados | 19:45:007:45 pm | Inter Division | |
| 2021-11-12 19:20:0012/11/2021 | Exmouth Knights vs Torbay Tigers | 19:20:007:20 pm | Inter Division | |
| 2021-11-14 10:15:0014/11/2021 | K&S Autos vs Crewkerne Thunder | 10:15:0010:15 am | Inter Division | |
| 2021-11-15 20:15:0015/11/2021 | Exeter University I vs Torbay Tigers | 20:15:008:15 pm | Division I | |
| 2021-11-16 19:15:0016/11/2021 | Spartan Nomads vs Exeter University II | 19:15:007:15 pm | Division I | |
| 2021-11-18 19:45:0018/11/2021 | QE Crediton Chargers vs K&S Autos | 19:45:007:45 pm | Division I | |
| 2021-11-18 20:15:0018/11/2021 | Torbay Tigers vs Newton Abbot Pacers | 20:15:008:15 pm | Inter Division | |
| 2021-11-20 18:15:0020/11/2021 | Exeter University II vs Exmouth Knights | 18:15:006:15 pm | Inter Division | |
| 2021-11-21 10:15:0021/11/2021 | K&S Autos vs North Devon | 10:15:0010:15 am | Inter Division | |
| 2021-11-23 19:15:0023/11/2021 | Spartan Nomads II vs QE Crediton Chargers | 19:15:007:15 pm | Inter Division | |
| 2021-11-24 20:15:0024/11/2021 | Newton Abbot Pacers vs K&S Autos | 20:15:008:15 pm | Inter Division | |
| 2021-11-25 20:15:0025/11/2021 | Torbay Tigers vs North Devon | 20:15:008:15 pm | Inter Division | |
| 2021-11-26 19:20:0026/11/2021 | Exmouth Knights vs Exeter University I | 19:20:007:20 pm | Inter Division | |
| 2021-11-26 20:15:0026/11/2021 | Taunton Tornados vs Spartan Nomads | 20:15:008:15 pm | Inter Division | |
| 2021-11-27 18:15:0027/11/2021 | Exeter University II vs Crewkerne Thunder | 18:15:006:15 pm | Inter Division | |
| 2021-11-29 20:15:0029/11/2021 | Exeter University I vs QE Crediton Chargers | 20:15:008:15 pm | Division I | |
| 2021-11-30 19:15:0030/11/2021 | Spartan Nomads II vs Exeter University I | 19:15:007:15 pm | Inter Division | |
| 2021-12-02 20:15:0002/12/2021 | Torbay Tigers vs Exeter University II | 20:15:008:15 pm | Division I | |
| 2021-12-03 20:15:0003/12/2021 | Taunton Tornados | 20:15:008:15 pm | Inter Division | |
| 2021-12-05 10:15:0005/12/2021 | K&S Autos vs Spartan Nomads | 10:15:0010:15 am | Division I | |
| 2021-12-08 20:15:0008/12/2021 | Newton Abbot Pacers vs QE Crediton Chargers | 20:15:008:15 pm | Inter Division | |
| 2021-12-09 19:15:0009/12/2021 | North Devon vs Exeter University II | 19:15:007:15 pm | Inter Division | |
| 2021-12-09 20:15:0009/12/2021 | Crewkerne Thunder vs Torbay Tigers | 20:15:008:15 pm | Inter Division | |
| 2021-12-10 19:20:0010/12/2021 | Exmouth Knights vs K&S Autos | 19:20:007:20 pm | Inter Division | |
| 2021-12-14 19:15:0014/12/2021 | Spartan Nomads II vs Spartan Nomads | 19:15:007:15 pm | Inter Division | |
| 2022-01-04 20:15:0004/01/2022 | Taunton Tornados vs Torbay Tigers | 20:15:008:15 pm | Inter Division | |
| 2022-01-06 19:45:0006/01/2022 | QE Crediton Chargers vs Spartan Nomads | 19:45:007:45 pm | Division I | |
| 2022-01-10 18:15:0010/01/2022 | Exeter University II vs Exeter University I | 18:15:006:15 pm | Division I | |
| 2022-01-11 19:15:0011/01/2022 | Spartan Nomads II vs Exeter University II | 19:15:007:15 pm | Inter Division | |
| 2022-01-16 10:15:0016/01/2022 | K&S Autos vs Torbay Tigers | 10:15:0010:15 am | Division I | |
| 2022-01-17 20:15:0017/01/2022 | Exeter University I vs Spartan Nomads | 20:15:008:15 pm | Division I | |
| 2022-01-18 19:15:0018/01/2022 | Spartan Nomads vs Exmouth Knights | 19:15:007:15 pm | Inter Division | |
| 2022-01-20 20:15:0020/01/2022 | Torbay Tigers vs QE Crediton Chargers | 20:15:008:15 pm | Division I | |
| 2022-01-23 10:15:0023/01/2022 | K&S Autos vs Exeter University II | 10:15:0010:15 am | Division I | |
| 2022-02-03 19:45:0003/02/2022 | QE Crediton Chargers vs Exeter University I | 19:45:007:45 pm | Division I | |
| 2022-02-05 18:15:0005/02/2022 | Exeter University II vs Torbay Tigers | 18:15:006:15 pm | Division I | |
| 2022-02-06 10:15:0006/02/2022 | K&S Autos vs Taunton Tornados | 10:15:0010:15 am | Inter Division | |
| 2022-02-06 10:15:0006/02/2022 | K&S Autos vs Exeter University I | 10:15:0010:15 am | Division I | |
| 2022-02-14 20:15:0014/02/2022 | Exeter University II vs Spartan Nomads | 20:15:008:15 pm | Division I | |
| 2022-02-17 20:15:0017/02/2022 | Torbay Tigers vs Exeter University I | 20:15:008:15 pm | Division I | |
| 2022-02-24 19:45:0024/02/2022 | QE Crediton Chargers vs Exeter University II | 19:45:007:45 pm | Division I | |
| 2022-03-01 19:15:0001/03/2022 | Spartan Nomads vs Torbay Tigers | 19:15:007:15 pm | Division I | |
